Small-scale GMP production of plasmid DNA using a simplified and fully disposable production method
Induction and analysis of oxidative stress in sleeping beauty transposontransfected human retinal pigment epithelial cells
Isolation, culture, and genetic engineering of mammalian primary pigment epithelial cells for non-viral gene therapy
Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina
Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery
Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization
Electroporation-based genetic modification of primary human pigment epithelial cells using the sleeping beauty transposon system
Antiangiogenic and Neurogenic Activities of Sleeping Beauty ‑Mediated PEDF-Transfected RPE Cells In Vitro and In Vivo
GMP-grade manufacturing and quality control of a non-virally engineered advanced therapy medicinal product for personalized treatment of agerelated macular degeneration
Transplantation of PEDF-transfected pigment epithelial cells inhibits corneal neovascularization in a rabbit model
Molecular and Functional Characterization of BDNFOverexpressing Human Retinal Pigment Epithelial Cells Established by Sleeping Beauty Transposon-Mediated Gene Transfer
The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells
Transposon-Based, Targeted Ex Vivo Gene Therapy to Treat Age-Related Macular Degeneration (TargetAMD)
Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids
Functional and anatomical characterization of atrophic age-related macular degeneration in an aged mouse model