Publications

TargetAMD Formation en ophtalmologie

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Small-scale GMP production of plasmid DNA using a simplified and fully disposable production method
Induction and analysis of oxidative stress in sleeping beauty transposontransfected human retinal pigment epithelial cells
Isolation, culture, and genetic engineering of mammalian primary pigment epithelial cells for non-viral gene therapy
Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina
In Vivo and Ex Vivo Gene Electrotransfer in Ophthalmological Disorders
Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery
Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization
Electroporation-based genetic modification of primary human pigment epithelial cells using the sleeping beauty transposon system
Antiangiogenic and Neurogenic Activities of Sleeping Beauty ‑Mediated PEDF-Transfected RPE Cells In Vitro and In Vivo
GMP-grade manufacturing and quality control of a non-virally engineered advanced therapy medicinal product for personalized treatment of agerelated macular degeneration
Transplantation of PEDF-transfected pigment epithelial cells inhibits corneal neovascularization in a rabbit model
Molecular and Functional Characterization of BDNFOverexpressing Human Retinal Pigment Epithelial Cells Established by Sleeping Beauty Transposon-Mediated Gene Transfer
The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells
Transposon-Based, Targeted Ex Vivo Gene Therapy to Treat Age-Related Macular Degeneration (TargetAMD)
Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids
Functional and anatomical characterization of atrophic age-related macular degeneration in an aged mouse model
The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi‑omics, mitochondria as a vital biosensor and AI‑based multi‑professional data interpretation
The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi‑omics, mitochondria as a vital biosensor and AI‑based multi‑professional data interpretation
Mammalian animal & human retinal organ culture as pre-clinical model to evaluate oxidative stress and antioxidant intraocular therapeutics
Enhanced Biosafety of the Sleeping Beauty Transposon System by using mRNA as Source of Transposase to efficiently and stably transfect Retinal Pigment Epithelial Cells
Short communication: Unique metabolic signature of proliferative retinopathy in the tear fluid of diabetic patients with comorbidities – Preliminary data for PPPM validation
Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications – Risks and mitigation
Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach
Tolbutamide eye drops increase aqueous humor outflow and lower intraocular pressure: A proof of concept for glaucoma treatment
AQP‑9, KCNJ11 and ABCC8 gene variants in open angle glaucoma: A hypothesis

Websites

Experimental Ophthalmology